- There is no single genetic mutation that accounts for cases of scleroderma
- Many patients with scleroderma have a family history of scleroderma or other autoimmune disease
- Certain ethnic groups (e.g., African Americans) have worse clinical outcomes from scleroderma
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- To collaborate with the NIH led GRASP (Genome Research in African American Scleroderma Patients) Study
- To identify genetic predictors of organ involvement and disease progression
- To identify biomarkers associated with worse outcomes
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